The map below indicates maintained air service to actively-served nonstop destinations from RDU. The following list includes all current and scheduled service, along with the airlines serving those destinations.
Seasonal and daily frequency could vary. See airline websites below for details.
| City | Airport Code | Served By |
|---|---|---|
| Akron, Ohio | CAK | Breeze |
| Albany, New York | ALB | Avelo |
| Atlanta, Georgia | ATL | Delta Frontier Southwest |
| Austin, Texas | AUS | American Delta Southwest |
| Baltimore-Washington, Maryland | BWI | Southwest |
| Boston, Massachusetts | BOS | Delta Frontier JetBlue |
| Buffalo, New York | BUF | Frontier |
| Burlington, Vermont | BTV | Breeze |
| Cancun, Mexico | CUN | American Delta JetBlue |
| Charlotte, North Carolina | CLT | American |
| Chicago, Illinois (Midway) | MDW | Southwest |
| Chicago, Illinois (O'Hare) | ORD | American Frontier United |
| Cincinnati, Ohio | CVG | American Delta Frontier |
| Cleveland, Ohio | CLE | Frontier |
| Columbus, Ohio | CMH | Breeze |
| Dallas, Texas (Fort Worth) | DFW | American Frontier |
| Dallas, Texas (Love Field) | DAL | Southwest |
| Denver, Colorado | DEN | Frontier Southwest United |
| Detroit, Michigan | DTW | Delta |
| Fort Lauderdale, Florida | FLL | Delta JetBlue Southwest Spirit |
| Fort Meyers, Florida | RSW | Avelo Breeze |
| Frankfurt, Germany | FRA | Lufthansa |
| Freeport, Bahamas | FPO | Bahamasair |
| Hartford, Connecticut | BDL | Breeze Frontier |
| Houston, Texas (Bush) | IAH | United |
| Houston, Texas (Hobby) | HOU | Southwest |
| Indianapolis, Indiana | IND | Frontier |
| Islip, New York | ISP | Breeze |
| Jacksonville, Florida | JAX | Breeze |
| Kansas City, Missouri | MCI | Southwest |
| Las Vegas, Nevada | LAS | Breeze Delta Southwest |
| London, United Kingdom (Heathrow) | LHR | American |
| Los Angeles, California | LAX | American Breeze Delta |
| Manchester, New Hampshire | MHT | Avelo |
| Mexico City, Mexico | MEX | Aeromexico |
| Miami, Florida | MIA | American Delta Frontier |
| Milwaukee, Wisconsin | MKE | Frontier |
| Minneapolis, Minnesota | MSP | Delta Sun Country |
| Montreal, Canada | YUL | Air Canada |
| Nashville, Tennessee | BNA | American Delta Southwest |
| New Haven, Connecticut | HVN | Avelo |
| New Orleans, Louisiana | MSY | Breeze |
| Newark, New Jersey | EWR | Delta United |
| New York, New York (Kennedy) | JFK | American Delta JetBlue |
| New York, New York (LaGuardia) | LGA | American Delta Frontier |
| Orlando, Florida (International) | MCO | Delta Frontier JetBlue Southwest |
| Panama City, Panama | PTY | Copa Airlines |
| Paris, France (Charles DeGaulle) | CDG | Air France |
| Philadelphia, Pennsylvania | PHL | American Frontier |
| Phoenix, Arizona | PHX | American Southwest |
| Pittsburgh, Pennsylvania | PIT | American Breeze Frontier |
| Portland, Maine | PWM | Breeze Frontier |
| Providence, Rhode Island | PVD | Breeze |
| Reykjavik, Iceland | KEF | Icelandair |
| Rochester, New York | ROC | Avelo |
| Salt Lake City, Utah | SLC | Delta |
| San Diego, California | SAN | Breeze |
| San Francisco, California | SFO | United |
| San Juan, Puerto Rico | SJU | Frontier JetBlue |
| Seattle, Washington | SEA | Alaska Delta |
| St. Louis, Missouri | STL | Southwest |
| Syracuse, New York | SYR | Breeze Frontier |
| Tampa, Florida | TPA | American Breeze Delta Frontier Southwest |
| Toronto, Canada | YYZ | Air Canada |
| Trenton, New Jersey | TTN | Frontier |
| Washington, District of Columbia (Dulles) | IAD | United |
| Washington, District of Columbia (National) | DCA | American Delta |
| West Palm Beach, Florida | PBI | Breeze |
| White Plains, New York | HPN | Breeze |